Statins and Generics Lower Costs and Improve Patient Outcomes
Heart disease continues to be the leading cause of death in the U.S. , with an annual cost of about $252 billion in both direct and indirect expenses (2019–2020).1 2
However, the development of innovative statins, along with the introduction of generic options, has significantly altered the landscape of cardiovascular care. Not only have these medications reduced health care system costs in both the short and long term, but they’ve also improved outcomes for patients.
Statins, alongside other cardiovascular medications, have played a key role in fighting heart disease. Since their introduction, they’ve helped reduce cardiovascular disease events by 25% and overall mortality by 16%.3 The advent of generics in 2001 made these lifesaving medications more accessible and affordable for patients, as well as for the health care system as a whole.
Today, approximately one-third of American adults rely on statins, making them one of the most commonly prescribed classes of medication.4 These cholesterol-lowering drugs continue to be highly effective for a wide range of patients, offering both low upfront costs and the potential for preventing serious cardiovascular events.
The cost savings from statins following the introduction of generics have been substantial, with total savings (including both direct and indirect costs) now reaching $41 billion per year.5

1 CDC. Heart Disease Facts. October 2024.
2 American Heart Association. 2024 Heart Disease and Stroke Statistics Update Fact Sheet. 2024.
3 Vasc Health Risk Manag. Benefits of statin therapy and compliance in high risk cardiovascular patients. October 2010.
4 Saudi Pharmaceutical Journal. Statins utilization trends and expenditures in the U.S. before and after the implementation of the 2013 ACC/AHA guidelines. April 2023.
5 McKinsey analysis of data from American Heart Association, IQVIA, Journal of Clinical Lipidology, British Journal of Clinical Pharmacology.
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